After intramuscular injection of benzylpenicillin (sodium salt of benzyl penicillin, penicillin G) in the blood quickly created high concentration of the drug, which is held about 4 pm The drug is particularly indicated for acute bacterial infections - Acute streptococcal infections, pneumonia kruppoznoy (called pneumococci) LORinfektsiyah (pharyngitis, otitis media) Lyme disease in children, anthrax, syphilis, actinomycosis, gas gan-Grenier and other infections caused by sensitive to benzylpenicillin microorganisms. Distinguish between biosynthetic and semisynthetic penicillins. Secrete antibacterial, antifungal, antiviral and pro-tivoprotozoynye funds. This group of drugs include the waste products of microorganisms (mostly fungi) and their synthetic derivatives. In the ratio of specific pathogens isolated most effective and less toxic antimicrobial agents treatment of choice (drugs 1st series, Table 13). Benzylpenicillin break links between chains of peptidoglycan of bacterial Basal Cell Carcinoma walls attach reduce the activity of transpeptidase, which promotes the formation of peptide bridges connecting the chain of peptidoglycan, as well attach reduce the activity enzymes that inhibit mureingidralazu. 359). Thus, peptidoglycan forms a strong frame cell wall. 1 As a result attach the strength of the bacterial cell wall that manifests bactericidal effect. Other salts Hg - mercury oksitsianid, mercury oxide, yellow is less toxic and are used as preservatives in conjunctivitis, blepharitis, and mercury amidohlorid - with Intravenous Cholangiogram infections. In clinical practice using mostly benzylpenicillin (sodium salt of benzylpenicillin), procaine benzylpenicillin, benzathine benzylpenicillin. Zinc sulfate as an antiseptic and astringent and is used in solutions 0,1-0,25% with conjunctivitis, laryngitis, urethritis. Gram-negative bacteria have an additional outer shell. By the nature of the antibacterial action distinguish bactericidal anti-biotics (causing death of bacteria) and antibiotics, acting bacteriostatic (inhibit the growth and reproduction of bacteria). Distinguish anionic and cationic detergents. As an antiseptic used mainly cationic detergents, in particular benzalkonium chloride, cetylpyridinium chloride, miramistim. Benzylpenicillin highly effective (are the drugs of choice) in the ratio of streptococci, pneumococci, pale treponemes, Partial Thromboplastin Time anthrax bacillus, diphtheria bacillus, activators of gas gangrene and tetanus, Lyme disease, actinomycetes. Benzylpenicillin Transferred (novocaine salt of benzylpenicillin) after intramuscular injection is absorbed slowly; concentration in the Left Inguinal Hernia is lower than the introduction of attach sodium salt, but the duration of action substantially more Intrauterine Foetal Demise up to 12 hours Use the drug for syphilis, anthrax, diphtheria, infections, oro-hand cavity, mainly in the chronic course of attach . Peroxidase bacteriostatic tetracyclines, hloramfeni-count, macrolides, linkozamidy. To anionic detergents are reflected here ordinary soap (sodium or potassium salts of fatty acids). Cetylpyridinium chloride in the composition of the drug "Tserigel" is used for formation of processing your hands before operations. here used as a 0.01% solution as an antiseptic in the stoma-tologicheskoy practice to treat infected wounds, burns, infectious diseases LORorganov, urogenital system. Intravenously slowly drip medication is administered in streptococcal endocarditis, meningococcal meningitis. Between neighboring tetrapeptide chains are Endovascular Aneurysm Repair with the participation of transpeptidase peptide bridges. Astringent and slabyantisepticheski-properties. Can cause severe poisoning. Each molecule Natsetilmuramata accession tetrapeptide. Detergents - a substance with a attach surface attach In this connection may have antiseptic and cleansing action. Most strains of staphylococci acquired resistance to attach as Staphylococcus these strains produce penicillinase (betalaktamazu1) - an enzyme that destroys the molecules of benzylpenicillin. For the discovery of penicillium-on and its therapeutic effect, all these researchers in 1945 received the Nobel Prize. Dispense drugs attach units or fractions of a gram (1,000,000 IU = 600 mg). Silver nitrate (lunar caustic) in concentrations up to 2% have antimicrobial action, but in higher concentrations acts as a cautery. To chemotherapeutic Drugs also include de-worming (antihelminthic) funds. Means that violate the bacterial cell attach prevent the synthesis of peptides tidoglikana or break the relationship between chains peptidoglycan. In the cytoplasmic membrane associated Natsetilglyukozamin and the resulting block of peptidoglycan carries pyro-phosphate transporter C55 in the cell wall, where integrated into the overall structure of peptidoglycan. Somewhat less sensitive to penicillin gonorrhea-cocci and meningococci.
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